Lezaa Biotech

This is a combination of two medicines: Pregabalin and Nortriptyline. Pregabalin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves).

Our formulation contains Methylcobalamin, Alpha Lipoic Acid, Folic Acid, Pyridoxine and Thiamine uniquely formulated for neurological support. This product contains nutrients for nerve & brain health.It supports healthy nerve functioning as it promotes optimal function of central and peripheral nerves. Additionally it helps in preventing oxygen free radicals and oxidative damage whilst stimulating nerve growth and simultaneously targets factors that lead to neuro-degeneration.Furthermore, its nutrient profile helps to support mental alertness and overall brain health. It also enhances energy and stamina levels. It is mainly useful for people suffering from neurological pains, sciatica pain, diabetic neuropathy and neuralgia.There are numerous conditions associated with neuro-degeneration. These conditions are becoming more and more prevalent due to environmental toxicity, and poor diet with subsequent nutritional deficiencies. Mitochondrial insufficiencies appear to be at the root of neuro degeneration. The mitochondria, important cellular powerhouses, are also significant source of free radical production, even in healthy individuals

Pregabalin And Methylcobalamin Combination Is Used Various Nerve Pain Conditions Like Fibromyalgia Or Diabetic Neuropathy .Side Effects of Pregabalin 75mg + Methylcobalamin 750mcg:Dizziness, Drowsiness, Visual Disturbance (Including Blurred Vision, Diplopia), Ataxia, Dysarthria, Tremor, Lethargy, Memory Impairment, Euphoria, Wt Gain, Constipation, Dry Mouth, Peripheral Edema, Depression, Confusion, Agitation, Hallucinations, Myoclonus, Hypoaesthesia, Hyperaesthesia, Tachycardia, Excessive Salivation, Sweating, Flushing, Rash, Muscle Cramp, Myalgia, Arthralgia, Urinary Incontinence, Dysuria, Thrombocytopenia, Neutropenia, 1st ° Heart Block, Hypotension, Hypertension, Pancreatitis, Dysphagia, Oliguria, Rhabdomyolysis.Drug Interactions of Pregabalin 75mg + Methylcobalamin 750mcg:Concurrent Use With , And Ethanol May Increase The CNS Effects.Contraindications of Pregabalin 75mg + Methylcobalamin 750mcg:Hypersensitivity. Pregnancy, Lactation. Driving Or Working With Machines, Or Do Other Dangerous Activities.Mechanism of Action of Pregabalin 75mg + Methylcobalamin 750mcg:Pregabalin Is An Analog Of The Neurotransmitter GABA. It Binds Potently To The Alpha2-Delta Subunit Resulting In Modulation Of Ca Channels And Reduction In The Release Of Several Neurotransmitters, Including Glutamate, Norepinephrine, Serotonin, Dopamine, And Substance P. Absorption: Rapidly Absorbed After Oral Doses. Peak Plasma Concentrations Are Achieved Within 1.5 Hr. Distribution: Not Bound To Plasma Proteins. Metabolism: Negligible Metabolism. Excretion: About 98% Excreted Unchanged In Urine. Elimination Half Life: About 6.3 Hr.Special Precautions for Pregabalin 75mg + Methylcobalamin 750mcg:Discontinue Treatment If Patients Develop Severe Angioedema. Withdraw Treatment Gradually Over At Least 1 Wk. May Cause Peripheral Oedema. Regular Vision Check Is Recommended. May Decrease Platelet Count And Prolong PR Interval.